MO Senate Candidates for Missouri Senator Election Race

The first European settlers were mostly ethnic French Canadians, who created their first settlement in Missouri at present-day Sainte-Geneviève, about an hour south of St. Louis. They had migrated about 1750 from the Illinois Country. They came from colonial villages on the east side of the Mississippi River, where soils were becoming exhausted and there was insufficient river bottom land for the growing population. Sainte-Geneviève became a thriving agricultural center, producing enough surplus wheat, corn and tobacco to ship tons of grain annually downriver to Lower Louisiana for trade. Grain production in the Illinois Country was critical to the survival of Lower Louisiana and especially the city of New Orleans.

St. Louis was founded soon after by French from New Orleans in 1764. From 1764 to 1803 European control of the area west of the Mississippi to the northernmost part of the Missouri River basin, called Louisiana, was assumed by the Spanish as part of the Viceroyalty of New Spain, due to Treaty of Fontainebleau (in order to have Spain join with France in the war against England). The arrival of the Spanish in St. Louis was in September 1767.

It became the center of a regional fur trade with Native American tribes that extended up the Missouri and Mississippi rivers, which dominated the regional economy for decades. Trading partners of major firms shipped their furs from St. Louis by river down to New Orleans for export to Europe. They provided a variety of goods to traders, for sale and trade with their Native American clients. The fur trade and associated businesses made St. Louis an early financial center and provided the wealth for some to build fine houses and import luxury items. Its location near the confluence of the Illinois River meant it also handled produce from the agricultural areas. River traffic and trade along the Mississippi were integral to the state's economy, and as the area's first major city, St. Louis expanded greatly after the invention of the steamboat and the increased river trade.